The current AFC South-leading Titans welcome the San Francisco 49ers to Nashville on ‘Thursday Night Football’ to kick off Week 16 of the NFL season. Will the Titans be able to turn around their recent poor form with a win in front of their home crowd, or will San Francisco win a third straight game for the second time this season? 

Deebo Samuel is a player we’ve tipped on this site often this season, and for good reason, considering how he’s been playing. The versatile offensive weapon has seven TDs in his last five games, six of which have come on the ground as his usage in the running game has increased in recent weeks. Deebo has 35+ rushing yards in four of his last five games and should go close to that number again tonight. 

Spread: Titans +3.5

Total: 46.0

Game Prediction: Niners 27-24 Titans

Best Bet: Deebo Samuel over 33.5 rushing yards & to score a TD @ 12/5 with Bet365 Bet Builder. [0.5]

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